✦ LIBER ✦

The occurrence of SV40-neutralizing antibodies in sera of patients with genitourinary carcinoma

✍ Scribed by Keerti V. Shah; Loreto D. Palma; Gerald P. Murphy

Publisher: John Wiley and Sons
Year: 1971
Tongue: English
Weight: 398 KB
Volume: 3
Category: Article
ISSN: 0022-4790
DOI: 10.1002/jso.2930030410

No coin nor oath required. For personal study only.

✦ Synopsis

Neutralizing antibodies to simian virus 40 (SV40) were detected in sera of seven of 182 patients studied a t the Roswell Park Memorial Institute. Four of 91 (4.4%) bladder tumor patients, two of 24 (8.3%) patients with prostatic carcinoma, and one of four patients with testicular tumors had antibodies. Neutralizing antibodies were demonstrable in repeated bleedings over a 5-11 month period. T antibodies were not detected in any of the sera. None of the antibody-positive patients gave a history of immunization with (potentially SV40-contaminated) poliovirus vaccines, the only known source of major human exposure to SV40 in the United States. These findings suggest that the seven antibody-positive donors were infected with a virus cross-reacting with SV40 or that infection with SV40 may have occurred in some unknown manner.

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