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The occurrence of deletions and point mutations in the estrogen receptor gene in breast cancer specimens

โœ Scribed by John H.R. Winstanley; Shanez Irwin; Roger Barraclough; Ross Sibson


Book ID
117666531
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
153 KB
Volume
34
Category
Article
ISSN
0959-8049

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Mutations in the estrogen receptor gene
โœ Mels Sluyser ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 674 KB

Somatically generated mutations in the estrogen receptor (ER) have been found at the mRNA/cDNA level in human breast cancer biopsies and in established breast cancer cell lines. Aberrantly spliced ER mRNA causes the appearance of truncated or internally deleted ER protein forms. Studies on the funct