The nucleolus—guardian of cellular homeostasis and genome integrity
✍ Scribed by Grummt, Ingrid
- Book ID
- 121799193
- Publisher
- Springer
- Year
- 2013
- Tongue
- English
- Weight
- 578 KB
- Volume
- 122
- Category
- Article
- ISSN
- 0009-5915
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## Abstract The nucleolus is a region of the nucleus with high protein density and it acts as a ribosome factory. The nucleolus contains a distinct region of the genome, the ribosomal RNA gene repeats (rDNA) that supply ribosomal RNA (rRNA) molecules. The rDNA is the most‐abundant gene and occupies
## Abstract Small non‐coding RNAs comprise several classes and sizes, but all share a unifying function in cellular physiology: epigenetic regulation of gene expression. Here, we review the salient aspects of recent studies on the biogenesis and function of three classes of small RNAs: miRNAs, siRN