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The NPM-ALK and the ATIC-ALK Fusion Genes Can Be Detected in Non-Neoplastic Cells

✍ Scribed by Brigitte Maes; Vera Vanhentenrijk; Iwona Wlodarska; Jan Cools; Benjamin Peeters; Peter Marynen; Christiane De Wolf-Peeters

Book ID: 117022326
Publisher: American Society for Investigative Pathology
Year: 2001
Tongue: English
Weight: 170 KB
Volume: 158
Category: Article
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)64690-1

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## Abstract The t(2;5)(p23;q35) translocation results in the formation of a unique chimeric NPM‐ALK protein (p80). Expression of this protein is considered to be one of the clinical features of anaplastic large cell lymphoma (ALCL). Recently recognized as one clinical subtype of ALCL, the small cel