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The novel κ-opioid receptor agonist TRK-820 suppresses the rewarding and locomotor-enhancing effects of morphine in mice

✍ Scribed by Minoru Tsuji; Hiroshi Takeda; Teruhiko Matsumiya; Hiroshi Nagase; Minoru Narita; Tsutomu Suzuki


Book ID
117172824
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
81 KB
Volume
68
Category
Article
ISSN
0024-3205

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## Opioid receptor agonists (e.g.,488) increase the locomotor activity of preweanling rats, while the same drugs depress the locomotor activity of adults. Curiously, direct stimulation of dopamine (DA) D 2 -like receptors fully attenuates the U-50,488-induced locomotor activity of preweanling rats