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The novel type I serine–threonine kinase receptor Alk8 binds TGF-β in the presence of TGF-βRII

✍ Scribed by Mark P de Caestecker; Martyn Bottomley; Sucharita Bhattacharyya; Tracie L Payne; Anita B Roberts; Pamela C Yelick


Book ID
117051904
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
625 KB
Volume
293
Category
Article
ISSN
0006-291X

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Transforming growth factor-beta (TGF-beta) signaling is initiated following heterodimerization of the type II TGF-beta receptor (TbetaRII) with the type I TGF-beta receptor (TbetaRI). Both receptors are required for TGF-beta responsiveness. In the present study, we characterized the actions of TGF-b