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The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival

✍ Scribed by Scuto, A; Krejci, P; Popplewell, L; Wu, J; Wang, Y; Kujawski, M; Kowolik, C; Xin, H; Chen, L; Wang, Y

Book ID
109887324
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
889 KB
Volume
25
Category
Article
ISSN
0887-6924

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## Abstract Aberrant janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling is involved in the oncogenesis of several cancers. Suppressors of cytokine signaling (SOCS) genes and SH2‐containing protein tyrosine phosphatase 1 (SHP1) proteins, which are negative regulator