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The novel endoplasmic reticulum (ER)-targeted protein HAP induces cell apoptosis by the depletion of the ER Ca2+ stores

✍ Scribed by Xiaoling Qu; Yipeng Qi; Ping Lan; Qilan Li


Book ID
117104676
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
335 KB
Volume
529
Category
Article
ISSN
0014-5793

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## Abstract HAP (a homologue of the ASY/Nogo-B protein), a novel human apoptosis-inducing protein, was found to be identical to RTN3. In an earlier study, we demonstrated that HAP localized exclusively to the endoplasmic reticulum (ER) and that its overexpression could induce cell apoptosis via a d