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The Notch signaling cascade in neuroblastoma: role of the basic helix-loop-helix proteins HASH-1 and HES-1

✍ Scribed by Håkan Axelson


Book ID
117467941
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
139 KB
Volume
204
Category
Article
ISSN
0304-3835

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HES-1 is a vertebrate homologue of the Drosophila basic helix-loop-helix (bHLH) protein Hairy, a transcriptional repressor that negatively regulates neuronal differentiation. HES-1 expression in neuronal precursors precedes and represses the expression of the neuronal commitment gene MASH-1, a bHLH