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The Notch Ligands, Delta1 and Jagged2, Are Substrates for Presenilin-dependent "gamma -Secretase" Cleavage

✍ Scribed by Ikeuchi, T.


Book ID
118123571
Publisher
The American Society for Biochemistry and Molecular Biology
Year
2003
Tongue
English
Weight
136 KB
Volume
278
Category
Article
ISSN
0021-9258

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## Abstract The presenilin/γ‐secretase protease cleaves many type‐I membrane proteins, including the amyloid β‐protein (Aβ) precursor (APP). Previous studies have shown that apoptosis induces alterations in Aβ production in a caspase‐dependent manner. Here, we report that staurosporine (STS)‐induce