The normal c-wave amplitude in rabbits

✍ Scribed by Nobuhisa Nao-I; Si-Yeol Kim; Yoshihito Honda

• Publisher: Springer-Verlag
• Year: 1986
• Tongue: English
• Weight: 437 KB
• Volume: 63
• Category: Article
• ISSN: 0012-4486
• DOI: 10.1007/bf00157121

✦ Synopsis

We examined some of the problems arising when c-waves are employed in pharmacological experiments with pigmented rabbits. The cyclic variations of the c-wave axe smaller in rabbit than in other species. Under our experimental conditions the cwave amplitudes in some rabbi.ts reached an equilibrium under intermittent stimuli, while in others they increased with time and did not reach a constant level within 3 h. The c-wave amplitude varied with the standing potential during dark adaptation. However interindividual variations made it difficult to standardize the c-waves by this change. Since the c-wave amplitudes of the right and left eyes were similar, the contralateral eye should be used as a control when drugs are administered topically. Interindividual variations of the c-wave amplitude were smaller under dim light. This method is useful in chronic pharmacological experiments when drugs are administered systemically.