The non-metabolite residue a limitation to the tracer method

✍ Scribed by Charles Rosenblum; Nelson R. Trenner; Donald E. Wolf

• Book ID: 102374956
• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: French
• Weight: 415 KB
• Volume: 7
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2590070304

✦ Synopsis

Abstract

The occurrence of non‐metabolite residues from labeled drugs administered to animals is discussed. Selected are ^14^C‐labeled thiabendazole, nitroglycerine, nortriptyline, amitryptiline, p‐dime‐thylaminobenzene, nihydrazone and ronidazole. The rapid degradation which is responsible for the phenomenon requires that all tracer applications in living systems be accompanied by a demonstration of the biological stability of the parent compound.