The non-enzymatic inactivation of thirteen β-lactam antibiotics in human faeces

Simple strategy of reactivation of a par

Simple strategy of reactivation of a partially inactivated penicillin g acylase biocatalyst in organic solvent and its impact on the synthesis of β-lactam antibiotics

✍ Oscar Romero; José Vergara; Roberto Fernández-Lafuente; José Manuel Guisán; Andr 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 144 KB 👁 2 views

## Abstract Some reactions of organic synthesis require to be performed in rather aggressive media, like organic solvents, that frequently impair enzyme operational stability to a considerable extent. We have studied the option of developing a reactivation strategy to increase biocatalyst lifespan