The noble gas xenon induces pharmacological preconditioning in the rat heart in vivo via induction of PKC-ɛ and p38 MAPK

Acidosis induces multi-drug resistance i

Acidosis induces multi-drug resistance in rat prostate cancer cells (AT1) in vitro and in vivo by increasing the activity of the p-glycoprotein via activation of p38

✍ Christoph Sauvant; Martin Nowak; Claudia Wirth; Bettina Schneider; Anne Riemann; 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 646 KB

## Abstract Because solid growing tumors often show hypoxia and pronounced extracellular acidosis, the aim of this study was to analyze the impact of an acidotic environment on the activity of the p‐glycoprotein (pGP) and on the cellular content and cytotoxicity of the chemotherapeutic drug daunoru