✦ LIBER ✦
The nm23 gene maps to human chromosome band 17q22 and shows a restriction fragment length polymorphism with bg/II
✍ Scribed by Lillana Varesco; Maria A. Caligo; Vincenzo Nardini; Generoso Bevilacqua; Lucia Casarino; Giovanbattista Ferrar; Paolo Simi; Mariano Rocchi; Donald M. Black; Ellen Solomon
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 429 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1045-2257
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The NM23‐HI gene is a putative tumor suppressor gene that may be important in the metastastic process. Recent genetic and immunological data indicate that the NM23‐HI gene encodes a protein with nucleoside diphosphate (NDP) kinase activity. The mapping of NM23‐HI by panels of rodent‐human somatic cell hybrids and in situ hybridization showed that the gene is located in human chromosome band 17q22. A two‐allele polymorphism with Bg/ll was demonstrated.