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The NLRP3 inflammasome is active but not essential in endotoxin-induced uveitis

✍ Scribed by Holly L. Rosenzweig; April Woods; Jenna S. Clowers; Stephen R. Planck; James T. Rosenbaum

Book ID
105753520
Publisher
SP Birkhäuser Verlag Basel
Year
2011
Tongue
English
Weight
373 KB
Volume
61
Category
Article
ISSN
1420-908X

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The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity
✍ Luigi Franchi; Gabriel Núñez 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 175 KB

## Abstract Aluminum hydroxide (alum) is the most widely used adjuvant in human vaccines, but the immune mechanisms that are activated by alum remain poorly understood. Alum has recently been shown to promote caspase‐1 activation and IL‐1β secretion, but the cellular pathways involved remain elusiv