The nitric oxide synthesis inhibitor nitro-L-arginine (L-NNA) attenuates nicotine abstinence syndrome in the rat
β Scribed by D. H. Malin; J. Ronald Lake; Merle Shenoi; Timothy P. Upchurch; Shun C. Johnson; Will E. Schweinle; Chris D. Cadle
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 124 KB
- Volume
- 140
- Category
- Article
- ISSN
- 0033-3158
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## Abstract **BACKGROUND:** To test whether the differentiating embryo is susceptible to the teratogenic effects of the nitric oxide (NO) synthesis inhibitor N^G^βnitroβLβarginine methyl ester (LβNAME). **METHODS:** ICRβ(CDβ1) mice received a single intraperitoneal injection of LβNAME at 90, 150, o
Department ot Internal Medicme, U n i i w ~z t v of We used the single-pass-perfused rat liver model to study short-term regulation of endotoxin-inducible nitric oxide synthesis by following the release of nitrite and nitrate, the oxidation products of nitric oxide, into the effluent perfusate. In e