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The nexus of iron and inflammation in hepcidin regulation: SMADs, STATs, and ECSIT

✍ Scribed by Elizabeth Milward; Daniel Johnstone; Debbie Trinder; Grant Ramm; John Olynyk

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
75 KB
Volume
45
Category
Article
ISSN
0270-9139

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✦ Synopsis

The negative effects of bile acids and tumor necrosis factor-alpha on the transcription of cholesterol 7alpha-hydroxylase gene (CYP7A1) converge to hepatic nuclear factor-4: a novel mechanism of feedback regulation of bile acid synthesis mediated by nuclear receptors.

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