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The Next Wave: Protein Tyrosine Phosphatases Enter T cell Antigen Receptor Signalling

✍ Scribed by Tomas Mustelin; Johannes Brockdorff; Lars Rudbeck; Anette Gjörloff-Wingren; Shulin Han; Xiaodong Wang; Pankaj Tailor; Manju Saxena

Book ID
114284211
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
458 KB
Volume
11
Category
Article
ISSN
0898-6568

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✍ Matthew L Thomas 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 830 KB

Antigen-receptor signaling requires Src-family kinases to initiate tyrosine phosphorylation. CD45 dephosphorylates the inhibitory site in Src-family kinases before antigen-receptor engagement and thus serves to 'prime' the kinases. It has been unclear why CD45 does not also dephosphorylate 'activate