The new potent and selective histamine H2receptor agonist amthamine as a tool to study gastric secretion
โ Scribed by Gabriella Coruzzi; Hendrik Timmerman; Maristella Adami; Giulio Bertaccini
- Book ID
- 112275215
- Publisher
- Springer-Verlag
- Year
- 1993
- Tongue
- English
- Weight
- 513 KB
- Volume
- 348
- Category
- Article
- ISSN
- 0028-1298
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๐ SIMILAR VOLUMES
A novel series of potent histamine H(3) receptor inverse agonists based on the 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one scaffold has been discovered. Several compounds display high selectivity over other histamine receptor subtypes and have favorable physicochemical properties, low potential for CY
## Abstract The inside cover picture shows the human histamine H~2~ receptor and the H~2~ and H~3~/H~4~ receptorโselective ligands identified. Bioisosteric replacement of the imidazole ring of the __N__^G^โacylโimidazolylpropylguanidine with 2โaminothiazole yielded potent and selective H~2~ recepto