✦ LIBER ✦
The neuropeptide Phe-Met-Arg-Phe-NH2(FMRFamide) can activate a ligand-gated ion channel inHelixneurons
✍ Scribed by G. A. Cottrell; K. A. Green; N. W. Davies
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 284 KB
- Volume
- 416
- Category
- Article
- ISSN
- 0031-6768
No coin nor oath required. For personal study only.
✦ Synopsis
Methods.
This report presents evidence that the molluscan neuropeptide FMRFamide can directly activate a ligand-gated ion channel in Helix neuroses. Using the patch-clamp technique we have observed unitary currents activated by the application of FMRFamide onto outside-out patches. As for the whole-cell response, Na+ ions are the main charge carriers. We conclude that FMRFamide may act as a fast depolarising neurotransmitter in the Hellx nervous system.