The neuronal stem cell of the olfactory epithelium

✍ Scribed by Calof, Anne L. ;Mumm, Jeffrey S. ;Rim, Peter C. ;Shou, Jianyong

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 501 KB
• Volume: 36
• Category: Article
• ISSN: 0022-3034
• DOI: 10.1002/(sici)1097-4695(199808)36:2<190::aid-neu7>3.0.co;2-x

✦ Synopsis

The vertebrate olfactory epithelium neuronal progenitors-which are in close physical (OE) is a system in which behavior of neuronal proproximity to ORNs-can ''read'' the number of difgenitor cells can be observed and manipulated easily. ferentiated neurons in their environment and regulate It is morphologically and functionally similar to emproduction of new neurons accordingly. Putative neubryonic germinal neuroepithelia, but is simpler in that ronal stem cells of the OE have been identified in vitro, it produces large numbers of a single type of neuron, and studies of these cells indicate that ORNs produce the olfactory receptor neuron (ORN). The OE is amea signal that feeds back to inhibit neurogenesis. This nable to tissue culture, gene transfer, and in vivo surgiinhibitory signal may be exerted at the level of the cal approaches, and these have been exploited in exstem cell itself. Recent studies to identify this signal, periments aimed at understanding the characteristics as well as endogenous stimulatory signals that may of OE neuronal progenitor cells. This has led to the be important in regulating OE neurogenesis, are also realization that the ORN lineage contains at least discussed. ᭧ 1998