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The neuroleptic drug, fluphenazine, blocks neuronal voltage-gated sodium channels

✍ Scribed by Xiaoping Zhou; Xiao-Wei Dong; Tony Priestley

Book ID
113501876
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
501 KB
Volume
1106
Category
Article
ISSN
0006-8993

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Anti-GM1 antibodies can block neuronal v
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Anti-GM1 antibodies, frequently found in the serum of patients with Guillain-BarrΓ© syndrome (GBS), have been suggested to interfere with axonal function. We report that IgG anti-GM1 antibodies, raised in rabbits, can reversibly block the voltage-gated Na(+) channels of nerve cells, thus causing a re