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The neonatal Fc receptor as therapeutic target in IgG-mediated autoimmune diseases

โœ Scribed by Alina Sesarman; Gestur Vidarsson; Cassian Sitaru

Publisher
Springer
Year
2010
Tongue
English
Weight
688 KB
Volume
67
Category
Article
ISSN
1420-682X

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Farnesoid X receptor (FXR) is a bile acid-activated transcription factor that is a member of the nuclear hormone receptor superfamily. FXR-null mice exhibit a phenotype similar to Byler disease, an inherited cholestatic liver disorder. In the liver, activation of FXR induces transcription of transpo