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The neonatal CNS is not conducive for encephalitogenic Th1 T cells and B cells during experimental autoimmune encephalomyelitis

✍ Scribed by Petra D Cravens, Bernd C Kieseier, Rehana Hussain…


Book ID
120690814
Publisher
BioMed Central
Year
2013
Tongue
English
Weight
567 KB
Volume
10
Category
Article
ISSN
1742-2094

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T cell co-stimulation through the CD28 receptor on T cells is critical to the induction of experimental autoimmune encephalomyelitis (EAE). In this study, expression of the co-stimulatory ligands B7-1 (CD80) and B7-2 (CD86), as well as the receptors CD28 and CTLA-4, were quantitated in central nervo