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The NBL1 tumor suppressor gene is downregulated in colon cancer by promoter methylation

✍ Scribed by Jimmy C. Sung; Susan McCarthy; Joel Turner; C.G. Li; Timothy J. Yeatman

Book ID
113676121
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
53 KB
Volume
199
Category
Article
ISSN
1072-7515

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## Abstract Retinoic acid receptor B2 (__RARB2__) is frequently inactivated in cancer. Methylation in the 5′‐untranslated region and first exon is known to play a role; however, few studies have analyzed the detailed methylation pattern of the promoter region. We show that hypo‐ and hypermethylated