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The nature of the genetic determinant for the SHV-1 β-lactamase

✍ Scribed by Nugent, M. E. ;Hedges, R. W.

Publisher
Springer
Year
1979
Tongue
English
Weight
438 KB
Volume
175
Category
Article
ISSN
0026-8925

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✦ Synopsis

In two unrelated plasmids of incompat-Table 1 ibility groups FII and N the gene for the SHV-1 fl-lactamase exists as part of a transposable element Plasmid of molecular weight 9.5 megadaltons. This transposon has moved onto plasmids of at least three incompatibility groups; PI, Ia and J. This confirms the suggestion that the recent spread of the SHV-1 fi-lactamase R1293 Rldrdl6 has been associated with the transposition of the genetic determinant of this enzyme between unrelated p453 plasmids.

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✍ Ki-Young Lee; John D. Hopkins; Michael Syvanen; Thomas F. O'Brien 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 607 KB

## Abstract The SHV‐type β‐lactamase SHV‐2A is related to SHV‐1 by a Gly‐238‐Ser replacement. Strains carrying SHV‐2A are resistant to the third generation cephems cefotaxime and ceftizoxime, whereas those that carry SHV‐1 are sensitive to these drugs. We present a kinetic analysis of a SHV‐1 and S