The nature of target-unrelated peptides recovered in the screening of phage-displayed random peptide libraries with antibodies
โ Scribed by Alfredo Menendez; Jamie K. Scott
- Book ID
- 108047773
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 227 KB
- Volume
- 336
- Category
- Article
- ISSN
- 0003-2697
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Most of the monoclonal antibodies (MAbs) raised against the fusion (F) protein of the bovine respiratory syncytial virus recognize discontinuous epitopes on the protein. In order to find mimotopes of these epitopes, phage-displayed peptide libraries were screened with MAbs. The results obtained with
## Abstract A random peptide library of heptamers displayed on the surface of M13 bacteriophage was used to identify specific epitopes of antibodies in pooled sera of swine naturally infected by Nipah virus. The selected heptapeptides were aligned with protein sequences of Nipah virus and several p