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The Natural Antibody Repertoire of Sharks and Humans Recognizes the Potential Universe of Antigens

✍ Scribed by Miranda K. Adelman; Samuel F. Schluter; John J. Marchalonis

Book ID
111594110
Publisher
Springer
Year
2004
Tongue
English
Weight
485 KB
Volume
23
Category
Article
ISSN
1573-4943

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## Abstract Studies of antibodies of known three‐dimensional structure have revealed that insertion and deletion of amino acids at the hypervariable loops change the canonical structures, thus generating differences in the antigen‐binding site topography. Such differences determine the size of the