The natriuresis produced by nitric oxide (NO) inhibition in the SHR is independent of changes in atrial natriuretic peptide (ANP)

Essential roles of the nitric oxide (no)

Essential roles of the nitric oxide (no)/cGMP/protein kinase G type-Iα (PKG-Iα) signaling pathway and the atrial natriuretic peptide (ANP)/cGMP/PKG-Iα autocrine loop in promoting proliferation and cell survival of OP9 bone marrow stromal cells

✍ Janica C. Wong; Ronald R. Fiscus 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 595 KB

## Abstract Inappropriate signaling conditions within bone marrow stromal cells (BMSCs) can lead to loss of BMSC survival, contributing to the loss of a proper micro‐environmental niche for hematopoietic stem cells (HSCs), ultimately causing bone marrow failure. In the present study, we investigate