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The Na+/K+-ATPase is the Achilles Heel of multi-drug-resistant cancer cells

โœ Scribed by Tatjana Mijatovic; Ute Jungwirth; Petra Heffeter; Mir Ali Reza Hoda; Rita Dornetshuber; Robert Kiss; Walter Berger

Book ID
116335184
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
304 KB
Volume
282
Category
Article
ISSN
0304-3835

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A reduction in the activity of the NA+,
A reduction in the activity of the NA+, K+ -pump in dimethylsulfoxide-treated friend erythroleukemia cells is not due to partial inactivation of the NA+, K+ -ATPase
โœ Andras Schaefer; Karl-Heinz Munter; Peter Geck; Gebhard Koch ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 706 KB

Treatment of Friend-erythroleukemia cells with 1.5% dimethylsulfoxide (DMSO) caused a decrease in ouabain sensitive 86Rb+-uptake beginning six to seven hours after DMSO addition indicating a reduced function of the Na+, K+-pump. However, analysis of the ouabain sensitive 86Rb+-uptake after Na+-prelo