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The N-terminal active centre of human angiotensin-converting enzyme degrades Alzheimer amyloid β-peptide

✍ Scribed by Ryutaro Oba; Akira Igarashi; Makiko Kamata; Kinya Nagata; Syoichi Takano; Hachiro Nakagawa


Book ID
109023797
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
418 KB
Volume
21
Category
Article
ISSN
0953-816X

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✍ Sotirios-Spyridon M. Vamvakas; Leondios Leondiadis; George Pairas; Evy Manessi-Z 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 421 KB

## Abstract We have cloned, over expressed, and purified one of the two catalytic domains (residues Ala^361^ to Gly^468^, ACE‐N) of human somatic angiotensin‐I converting enzyme in __Escherichia coli.__ This construct represents the __N__‐catalytic domain including the two binding motifs and the 23