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The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

✍ Scribed by Stransky, N.; Egloff, A. M.; Tward, A. D.; Kostic, A. D.; Cibulskis, K.; Sivachenko, A.; Kryukov, G. V.; Lawrence, M. S.; Sougnez, C.; McKenna, A.; Shefler, E.; Ramos, A. H.; Stojanov, P.; Carter, S. L.; Voet, D.; Cortes, M. L.; Auclair, D.; Berger, M. F.; Saksena, G.; Guiducci, C.; Onofrio, R. C.; Parkin, M.; Romkes, M.; Weissfeld, J. L.; Seethala, R. R.; Wang, L.; Rangel-Escareno, C.; Fernandez-Lopez, J. C.; Hidalgo-Miranda, A.; Melendez-Zajgla, J.; Winckler, W.; Ardlie, K.; Gabriel, S. B.; Meyerson, M.; Lander, E. S.; Getz, G.; Golub, T. R.; Garraway, L. A.; Grandis, J. R.

Book ID
118153773
Publisher
American Association for the Advancement of Science
Year
2011
Tongue
English
Weight
297 KB
Volume
333
Category
Article
ISSN
0036-8075

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## Loss of heterozygosity (LOH ) at chromosome band 10q23 occurs frequently in a wide variety of human tumors. A recently identified candidate tumor suppressor gene, PTEN located on 10q23, is mutated in multiple advanced cancers. To explore whether PTEN is associated with human squamous cell carci