๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

The mutagenic activity of anti-cancer drugs and the urine of rats given these drugs

โœ Scribed by Pak, Kyun ;Iwasaki, Takuo ;Miyakawa, Mieko ;Yoshida, Osamu

Publisher
Springer
Year
1979
Tongue
English
Weight
411 KB
Volume
7
Category
Article
ISSN
0300-5623

No coin nor oath required. For personal study only.

โœฆ Synopsis

Twenty-one anti-cancer drugs have been tested for their ability to cause mutations in Salmonella typhimurium test strains in the Salmonella/microsome mutagenicity test. Nine of the 21 anticancer drugs showed this ability: cyclophosphmide, nitromin, thio-tepa, busulfan, 6-mercaptopurine, neocarzinostatin, daunomycin, adriamycin and estramustine phosphate. Seven of these 9 mutagenic drugs were injected continuously into the jugular veins of rats. Urine was collected through a cystostomy tube and tested for mutagenicity. The urine from rats treated with 6 of these 7 drugs was mutagenic. These were cyclophosphamide, nitromin, thio-tepa, neocarzinostatin, adriamycin and daunomycin.

๐Ÿ“œ SIMILAR VOLUMES

Stability and inactivation of mutagenic
Stability and inactivation of mutagenic drugs and their metabolites in the urine of patients administered antineoplastic therapy
โœ D. K. Monteith; T. H. Connor; J. A. Benvenuto; E. J. Fairchild; J. C. Theiss ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 886 KB

Urine samples from patients administered mutagenic antineoplastic drugs are mutagenic in the Ames assay, and hence may pose a genotoxic hazard to hospital personnel or family members caring for the patient. The urine samples in the present study were tested for mutagenicity in several strains of Sal