## Development of one hundred or more adenomas in the colon and rectum is diagnostic for the dominantly inherited, autosomal disease Familial Adenomatous Polyposis (FAP). It is possible to identify a mutation in the Adenomatous Polyposis Coli (APC) gene in approximately 80% of the patients, and alm
The murine homolog of TB2/DP1, a gene of the familial adenomatous polyposis (FAP) locus
β Scribed by Eva E. Prieschl; Gunther G. Pendl; Nathalie E. Harrer; Thomas Baumruker
- Book ID
- 116133368
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 327 KB
- Volume
- 169
- Category
- Article
- ISSN
- 0378-1119
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π SIMILAR VOLUMES
Germline mutations in the tumor-suppresor APC gene are associated with hereditary familial adenomatous polyposis (FAP) and somatic mutations are common in sporadic colorectal cancer. In this study, we report the identification of three novel germline mutations: 1682-1683insA, 3252-3253insAT, 3544A>T
## BACKGROUND. Familial adenomatous polyposis (FAP) is a dominantly inherited disorder characterized by the presence of more than 100 adenomatous polyps in the colon and rectum starting in the second decade of life. FAP is associated with extra colonic manifestations, including desmoid tumors.