Left±right asymmetric signaling molecules in mammals include three transforming growth factor b (TGFb)-related factors, Nodal, Lefty1 and Lefty2. They are all expressed on the left half of developing mouse embryos. Nodal acts as a left-side determinant by transducing signals through Smad and FAST an
✦ LIBER ✦
The multiple roles of Notch signaling during left-right patterning
✍ Scribed by Yoichi Kato
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 420 KB
- Volume
- 68
- Category
- Article
- ISSN
- 1420-682X
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## Abstract Nodal factors play crucial roles during embryogenesis of chordates. They have been implicated in a number of developmental processes, including mesoderm and endoderm formation and patterning of the embryo along the anterior–posterior and left–right axes. We have analyzed the function of