The multiple and enigmatic roles of guanylyl cyclase C in intestinal homeostasis
β Scribed by Najla Arshad; Sandhya S. Visweswariah
- Book ID
- 118442915
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 349 KB
- Volume
- 586
- Category
- Article
- ISSN
- 0014-5793
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The heat-stable enterotoxin STa of E. coli causes diarrhea by binding to and stimulating intestinal membrane-bound guanylyl cyclase, triggering production of cyclic GMP. Agents which stimulate protein kinase C (PKC), including phorbol esters, synergistically enhance STa effects on cGMP and secretion
## Abstract Guanylyl cyclase C (GCβC), a transmembrane receptor for bacterial heatβstable enterotoxin and the mammalian peptides guanylin and uroguanylin, mediates intestinal ion secretion and affects intestinal cell growth via cyclic GMP signaling. In intestinal tumors, GCβC expression is maintain