✦ LIBER ✦

The multifaceted effects of granulocyte colony-stimulating factor in immunomodulation and potential roles in intestinal immune homeostasis

✍ Scribed by Andrew Martins; Jiahuai Han; Sung O. Kim

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 167 KB
Volume: 62
Category: Article
ISSN: 1521-6543
DOI: 10.1002/iub.361

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✦ Synopsis

Abstract

The three colony‐stimulating factors, granulocyte/macrophage colony‐stimulating factor (GM‐CSF), macrophage colony‐stimulating factor (M‐CSF), and granulocyte colony‐stimulating factor (G‐CSF), have been regarded as immunostimulators because of their role in granulocyte and myeloid hematopoiesis and immune function. However, unlike GM‐CSF and M‐CSF, G‐CSF possesses immunosuppressive effects on other immune cells including monocytes/macrophages, dendritic cells, and T lymphocytes when exogenously administered. Given the immunomodulatory effects of exogenous G‐CSF, endogenous G‐CSF may also play an important role in maintaining local immune homeostasis in tissue in which it is highly and constitutively produced. This review highlights the potential role of G‐CSF in immunomodulation and intestinal immune homeostasis. © 2010 IUBMB IUBMB Life, 62(8): 611–617, 2010.

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