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The multidrug resistance protein 1 (Mrp1), but not Mrp5, mediates export of glutathione and glutathione disulfide from brain astrocytes

✍ Scribed by Tobias Minich; Jan Riemer; Jörg B. Schulz; Peter Wielinga; Jan Wijnholds; Ralf Dringen

Book ID: 111179448
Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 221 KB
Volume: 97
Category: Article
ISSN: 0022-3042
DOI: 10.1111/j.1471-4159.2006.03737.x

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## Abstract To investigate the release of glutathione (GSH) from brain cells, cultures enriched for astroglial cells, neurons, oligodendroglial cells, and microglial cells derived from rat brain were studied. During incubation of astroglial cultures, GSH accumulated in the medium with a rate of 3.1