The mucins of the normal and cancerous uterine mucosa
โ Scribed by Richard B. Moore; James W. Reagan; Melvin D. Schoenberg
- Publisher
- John Wiley and Sons
- Year
- 1959
- Tongue
- English
- Weight
- 667 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0008-543X
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โฆ Synopsis
T IS OFTEN difficult to determine the site of I origin of adenocarcinomas involving the endocervical and endometrial mucosa. This distinction is important in view of the differences in therapy employed in the treatment of the tumors.
Both endocervical and endometrial cells are capable of secreting mucin. In many instances, the glandular lumina of normal mucosa and tumors originating from these cells contain an amorphous mucoid material. Based upon the premise that a tumor may retain in whole or in part the function of its cells of origin, the mucins of endocervical and endometrial mucosa were investigated. Differences between the intracellular mucins of normal endocervical and endometrial mucosa and those of adenocarcinomas arising from these areas are described.
Methods
The tissues selected for this study were from
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As oestrogen is associated with most of the epidemiological risk factors for breast cancer, the number and distribution of oestrogen receptor positive (ER+) cells could have a bearing on the development of the disease. ER+ cells were thus studied in the normal breast and in the spectrum of in situ p