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The MRE11-RAD50-NBS1 complex accelerates somatic hypermutation and gene conversion of immunoglobulin variable regions

✍ Scribed by Yabuki, Munehisa; Fujii, Monica M; Maizels, Nancy

Book ID: 109923130
Publisher: Nature Publishing Group
Year: 2005
Tongue: English
Weight: 356 KB
Volume: 6
Category: Article
ISSN: 1529-2908
DOI: 10.1038/ni1215

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## Abstract Mre11, Rad50, and Nbs1form a tight complex which is homogeneously distributed throughout the nuclei of mammalian cells. However, after irradiation, the Mre11/Rad50/Nbs1 (M/R/N) complex rapidly migrates to sites of double strand breaks (DSBs), forming foci which remain until DSB repair i