The mouse mammary carcinoma 4T1: characterization of the cellular landscape of primary tumours and metastatic tumour foci

Protection against MUC1 expressing mouse

Protection against MUC1 expressing mouse tumours by intra-muscular injection of MUC1 cDNA requires functional CD8+ and CD4+ T cells but does not require the MUC1 tandem repeat domain

✍ Tim Plunkett; Rosalind Graham; Isobel Correa; Robert Sewell; David Miles; Joy Bu 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 223 KB

## Abstract Using a C57Bl/6 mouse model system, where intramuscular (i.m.) injection of full length (FL) __MUC1__ cDNA protects against subsequent challenge with MUC1‐expressing syngeneic tumour cells, we have investigated the importance of the tandem repeat (TR) domain in the induction of T cell‐d