The Mouse Homologue of the Polycystic Kidney Disease Gene (Pkd1) Is a Single-Copy Gene
✍ Scribed by P.G. Olsson; C. Löhning; S. Horsley; L. Kearney; P.C. Harris; A.-M. Frischauf
- Book ID
- 115613229
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 183 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0888-7543
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Since identification of the genes mutated in patients with Autosomal Dominant Polycystic Kidney Disease, PKD1 and PKD2, a large number of different germ line mutations in both genes have been found by conventional PCR-based mutation detection methods. Nevertheless, in approximately 40% of the PKD1 f
Autosomal dominant polycystic kidney disease (ADPKD) is an inherited nephropathy, usually of late onset (onset between third to seventh decade), primarily characterized by the formation of fluid-filled cysts in the kidneys. It is one of the most frequent inherited conditions affecting approximately