The motor domains of ABC-transporters
β Scribed by Christine Oswald; I. Barry Holland; Lutz Schmitt
- Publisher
- Springer-Verlag
- Year
- 2006
- Tongue
- English
- Weight
- 590 KB
- Volume
- 372
- Category
- Article
- ISSN
- 0028-1298
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ABC transporters are a large superfamily of integral membrane proteins involved inATP-dependent transport across biological membranes. Members of this superfamily play roles in a number of phenomena of biomedical interest, including cystic fibrosis (CFTR) and multidrug resistance (P-glycoprotein, MR
ATP-binding cassette (ABC) transporters are members of a protein superfamily which can be responsible for efflux of drugs from cells of target organisms. In this way, the transporters may provide a mechanism of protection against cytotoxic drugs. In laboratory-generated mutants of fungi, overproduct