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The Montreal Cognitive Assessment: A screening tool for mild cognitive impairment in REM sleep behavior disorder

✍ Scribed by Jean-François Gagnon; Ronald B. Postuma; Steve Joncas; Catherine Desjardins; Véronique Latreille

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
488 KB
Volume
25
Category
Article
ISSN
0885-3185

No coin nor oath required. For personal study only.

✦ Synopsis

A correct balance between endocannabinoid and dopamine-dependent systems is believed to underlie physiological motor control. We measured the levels of the endocannabinoid anandamide in the cerebrospinal fluid of Parkinson's disease (PD) patients. Subjects were divided into three groups: newly diagnosed de novo patients, subjects undergoing drug withdrawal, and patients under pharmacological therapy. These groups were compared to age-matched control subjects. Anandamide levels in untreated patients were more than doubled as compared to controls. However, chronic dopaminergic replacement restored control anandamide levels. Abnormal anandamide increase might reflect a compensatory mechanism occurring in course of PD, aimed at normalizing dopamine depletion.

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