The monoclonal antibody MEL-14 can block lymphocyte migration into a site ofchronic inflammation
✍ Scribed by Janet Dawson; Anthony D. Sedgwick; Jonathan C. W. Edwards; Peter Lees
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 393 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0014-2980
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✦ Synopsis
The monoclonal antibody MEL-14 can block lymphocyte migration into a site of chronic inflammation*
The effect of MEL-14, a monoclonal antibody which binds to the lymphocyte homing receptor (MEL-14 Ag) on lymphocytes for peripheral lymph node (PLN) high endothelial venules (HEV), was investigated on lymphocyte migration into a delayed-type hypersensitivity (DTH)-like lesion produced by sensitization and challenge to Bordetella pertussis vaccine (BPV). Pretreatment of lymphocytes with saturating concentrations of MEL-14 caused a highly significant inhibition of lymphocyte migration into the chronically inflamed site and PLN. This finding suggests that lymphocyte migration into the BPV-induced site of chronic inflammation may be regulated by the same mechanism as lymphocyte migration into the PLN. It further indicates that the ligand for the MEL-14 Ag adhesion molecule, recognized by lymphocyte which home to the PLN, may also be expressed on HEV-like vessels at sites of BPV-induced chronic inflammation.