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The monocistronic nature of ribosomal protein genes in yeast

✍ Scribed by Charles Gorenstein; Jonathan R. Warner


Publisher
Springer-Verlag
Year
1979
Tongue
English
Weight
298 KB
Volume
1
Category
Article
ISSN
0172-8083

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✦ Synopsis


The synthesis of thirty five ribosomal proteins has been studied in Saccharomyces cerevisiae using a temperature sensitive mutant blocked in the initiation of polypeptides. The synthesis of all the ribosomal proteins was nearly equally affected by the block. This absence of polarity, together with previous genetic and biochemical data, indicates that eukaryotic ribosomal proteins are coded by monocistronic mRNAs.


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The rate of ribosome formation in yeast is precisely adjusted to the physiological demands of the cell. During all growth conditions a balance is maintained in the production of all ribosomal constituents. Coordinate expression of the ribosomal protein (rp) genes is primarily accomplished at the tra