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The Molecular Perspective: Double-Stranded DNA Breaks

✍ Scribed by David S. Goodsell

Book ID: 111846022
Publisher: AlphaMed Press
Year: 2005
Tongue: English
Weight: 166 KB
Volume: 23
Category: Article
ISSN: 1066-5099
DOI: 10.1634/stemcells.fcm4

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## Abstract DNA double‐strand breaks (DSBs) are the most hazardous lesions arising in the genome of eukaryotic organisms, and yet occur normally during DNA replication, meiosis, and immune system development. The efficient repair of DSBs is crucial in maintaining genomic integrity, cellular viabili