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The molecular pathophysiology of pain: abnormal expression of sodium channel genes and its contributions to hyperexcitability of primary sensory neurons

โœ Scribed by Stephen G. Waxman


Book ID
117480382
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
1009 KB
Volume
82
Category
Article
ISSN
0304-3959

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Sodium channels, excitability of primary
โœ Stephen G. Waxman; Theodore R. Cummins; Sulayman Dib-Hajj; Jenny Fjell; Joel A. ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 542 KB

Following nerve injury, primary sensory neurons (dorsal root ganglion [DRG] neurons, trigeminal neurons) exhibit a variety of electrophysiological abnormalities, including increased baseline sensitivity and/or hyperexcitability, which can lead to abnormal burst activity that underlies pain, but the