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The molecular mechanism underlying the reduction in abdominal fat accumulation by licorice flavonoid oil in high fat diet-induced obese rats

✍ Scribed by Kazuhisa HONDA; Hiroshi KAMISOYAMA; Yuji TOMINAGA; Shinichi YOKOTA; Shin HASEGAWA

Book ID
111669755
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
179 KB
Volume
80
Category
Article
ISSN
1344-3941

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## Abstract The effect of obesity induced by a high‐fat diet on the pharmacokinetics (PK) of nelfinavir (NFV) was investigated, focusing on the change of distribution and elimination caused by dyslipidemia and hepatic steatosis. The plasma unbound fraction (__f__~u~) of NFV in obese rats (0.61Β±0.0